Medical Secretary and Administrative Assistant Salary in Greenville, SC
Medical Secretaries and Administrative Assistants in the Greenville-Anderson-Greer, SC metro area earn a median $39,410 a year — 14% less than the national median. After 2026 taxes, that is $32,638 take-home, or $2,720 a month.
Take-home pay calculator
Pre-filled with the median medical secretary and administrative assistant salary in Greenville, SC. Enter your own offer to see your paycheck.
- Federal income tax$2,549
- Social Security (6.2%)$2,443
- Medicare (1.45%)$571
- South Carolina income tax$1,208
- Take-home pay$32,638
Marginal rate: 12% federal + 6.00% state
Got an offer somewhere else? Compare it with this one after taxes and rent →
Medical Secretary and Administrative Assistant pay by experience in Greenville, SC
| Percentile | Salary | Hourly | Take-home / yr | Per month |
|---|---|---|---|---|
| 10th percentile (entry level) | $35,610 | $17.12 | $29,813 | $2,484 |
| 25th percentile | $37,460 | $18.01 | $31,189 | $2,599 |
| Median (50th) | $39,410 | $18.95 | $32,638 | $2,720 |
| 75th percentile | $46,310 | $22.26 | $37,769 | $3,147 |
| 90th percentile (top earners) | $53,250 | $25.60 | $42,928 | $3,577 |
Wages: BLS Occupational Employment and Wage Statistics, May 2025. Take-home: single filer, South Carolina resident, 2026 tax rules.
What $39,410 buys in Greenville, SC
Prices in Greenville, SC are 6.7% lower than the U.S. average (housing costs are 23% below the national average). Adjusted for local prices, a median medical secretary and administrative assistant's $32,638 take-home pay has the buying power of $34,997 in a typical American city.
Rents: HUD Fair Market Rents, FY2026 (40th-percentile gross rent incl. utilities). Price levels: BEA Regional Price Parities, 2024.
Medical Secretary and Administrative Assistant jobs are about as common in Greenville, SC as in the U.S. overall (location quotient 1.15).
Best-paying cities for medical secretaries and administrative assistants, adjusted for cost of living
Greenville, SC ranks #62 of 69 metro areas once taxes and local prices are taken into account.
| # | Metro area | Median salary | Take-home | Real value* |
|---|---|---|---|---|
| 1 | San Jose, CA | $69,350 | $54,380 | $49,247 |
| 2 | Seattle, WA | $60,350 | $50,671 | $45,595 |
| 3 | Sacramento, CA | $57,730 | $46,302 | $43,407 |
| 4 | San Francisco, CA | $61,330 | $48,932 | $42,324 |
| 5 | Winston, NC | $46,370 | $38,097 | $41,390 |
| 6 | Cleveland, OH | $45,920 | $38,596 | $41,094 |
| 7 | Albuquerque, NM | $47,310 | $39,127 | $40,950 |
| 8 | Cincinnati, OH | $46,180 | $38,798 | $40,682 |
| 62 | Greenville, SC | $39,410 | $32,638 | $34,997 |
*Take-home pay divided by the BEA price level, so every city is measured in U.S.-average dollars. See all 69 metros →
About the job: medical secretaries and administrative assistants
Perform secretarial duties using specific knowledge of medical terminology and hospital, clinic, or laboratory procedures. Duties may include scheduling appointments, billing patients, and compiling and recording medical charts, reports, and correspondence.
- Typical education
- High school diploma or equivalent
- Work experience
- None required
- On-the-job training
- Moderate-term on-the-job training
- Job outlook, 2025–35
- +4.8% (about average)
Source: BLS Standard Occupational Classification and Employment Projections, 2025–35.
Medical Secretary and Administrative Assistant salaries elsewhere in South Carolina
- Charleston, SC — $44,640
Frequently asked questions
How much does a medical secretary and administrative assistant make in Greenville, SC?
The median medical secretary and administrative assistant salary in the Greenville-Anderson-Greer, SC metro area is $39,410 a year, or about $18.95 an hour, according to the Bureau of Labor Statistics (May 2025). The middle half earn between $37,460 and $46,310.
What is a medical secretary and administrative assistant’s take-home pay in Greenville, SC?
On the median $39,410 salary, a single filer living in South Carolina takes home about $32,638 a year ($2,720 a month) after federal tax, Social Security, Medicare and $1,208 in South Carolina taxes in 2026.
Is Greenville, SC a good place to work as a medical secretary and administrative assistant?
Pay here is 14% below the national median of $45,930. Local prices are 6.7% below the U.S. average, so the take-home pay buys what $34,997 would in a typical U.S. city. Greenville, SC ranks #62 of 69 metro areas for cost-of-living-adjusted pay in this job.
Can a medical secretary and administrative assistant afford rent in Greenville, SC?
HUD’s fair market rent for a one-bedroom in Greenville, SC is $1,155 a month ($1,288 for two bedrooms) — 42% of a median medical secretary and administrative assistant’s monthly take-home pay. Financial planners usually suggest keeping rent under about 30%.
Related jobs in Greenville, SC
- First-Line Supervisor of Office and Administrative Support Workers — $63,630
- Bookkeeping, Accounting, and Auditing Clerks — $49,600
- Secretaries and Administrative Assistants, Except Legal, Medical, and Executive — $46,120
- Shipping, Receiving, and Inventory Clerks — $44,540
- Customer Service Representative — $39,010
- Office Clerks, General — $36,030