Nurse Practitioner Salary in St. Louis, MO
Nurse Practitioners in the St. Louis, MO-IL metro area earn a median $131,580 a year — 1% less than the national median. After 2026 taxes, that is $95,954 take-home, or $7,996 a month.
Take-home pay calculator
Pre-filled with the median nurse practitioner salary in St. Louis, MO. Enter your own offer to see your paycheck.
- Federal income tax$20,313
- Social Security (6.2%)$8,158
- Medicare (1.45%)$1,908
- Missouri income tax$5,247
- Take-home pay$95,954
Marginal rate: 24% federal + 4.70% state
Living in St. Louis? City residents also pay St. Louis’s Earnings Tax — about $1,316 a year on this salary — which lowers take-home pay to $94,638 ($7,887 a month). Choose “St. Louis” under City income tax in the calculator. Suburban residents usually don’t pay it.
The St. Louis, MO-IL metro spans Missouri, Illinois. Pick the state you live in — state income tax follows your residence.
Got an offer somewhere else? Compare it with this one after taxes and rent →
Nurse Practitioner pay by experience in St. Louis, MO
| Percentile | Salary | Hourly | Take-home / yr | Per month |
|---|---|---|---|---|
| 10th percentile (entry level) | $108,340 | $52.09 | $80,893 | $6,741 |
| 25th percentile | $127,460 | $61.28 | $93,332 | $7,778 |
| Median (50th) | $131,580 | $63.26 | $95,954 | $7,996 |
| 75th percentile | $154,500 | $74.28 | $110,543 | $9,212 |
| 90th percentile (top earners) | $164,280 | $78.98 | $116,768 | $9,731 |
Wages: BLS Occupational Employment and Wage Statistics, May 2025. Take-home: single filer, Missouri resident, 2026 tax rules.
What $131,580 buys in St. Louis, MO
Prices in St. Louis, MO are 4.9% lower than the U.S. average (housing costs are 21% below the national average). Adjusted for local prices, a median nurse practitioner's $95,954 take-home pay has the buying power of $100,911 in a typical American city.
Rents: HUD Fair Market Rents, FY2026 (40th-percentile gross rent incl. utilities). Price levels: BEA Regional Price Parities, 2024.
St. Louis, MO has 1.2× the national concentration of nurse practitioner jobs — a strong local market for this occupation.
Best-paying cities for nurse practitioners, adjusted for cost of living
St. Louis, MO ranks #8 of 24 metro areas once taxes and local prices are taken into account.
| # | Metro area | Median salary | Take-home | Real value* |
|---|---|---|---|---|
| 1 | San Francisco, CA | $219,080 | $143,890 | $124,458 |
| 2 | Houston, TX | $134,560 | $103,238 | $104,673 |
| 3 | Cleveland, OH | $130,800 | $97,853 | $104,184 |
| 4 | Kansas City, MO | $130,760 | $95,432 | $103,122 |
| 5 | New York, NY | $163,340 | $114,312 | $101,554 |
| 6 | Cincinnati, OH | $128,700 | $96,476 | $101,159 |
| 7 | Indianapolis, IN | $130,460 | $96,616 | $100,962 |
| 8 | St. Louis, MO | $131,580 | $95,954 | $100,911 |
*Take-home pay divided by the BEA price level, so every city is measured in U.S.-average dollars. See all 24 metros →
About the job: nurse practitioners
Diagnose and treat acute, episodic, or chronic illness, independently or as part of a healthcare team. May focus on health promotion and disease prevention. May order, perform, or interpret diagnostic tests such as lab work and x rays. May prescribe medication. Must be registered nurses who have specialized graduate education.
- Typical education
- Master's degree
- Work experience
- None required
- On-the-job training
- None
- Job outlook, 2025–35
- +41.0% (much faster than average)
Source: BLS Standard Occupational Classification and Employment Projections, 2025–35.
Nurse Practitioner salaries elsewhere in Missouri
- Kansas City, MO — $130,760
Frequently asked questions
How much does a nurse practitioner make in St. Louis, MO?
The median nurse practitioner salary in the St. Louis, MO-IL metro area is $131,580 a year, or about $63.26 an hour, according to the Bureau of Labor Statistics (May 2025). The middle half earn between $127,460 and $154,500.
What is a nurse practitioner’s take-home pay in St. Louis, MO?
On the median $131,580 salary, a single filer living in Missouri takes home about $95,954 a year ($7,996 a month) after federal tax, Social Security, Medicare and $5,247 in Missouri taxes in 2026.
Is St. Louis, MO a good place to work as a nurse practitioner?
Pay here is 1% below the national median of $132,300. Local prices are 4.9% below the U.S. average, so the take-home pay buys what $100,911 would in a typical U.S. city. St. Louis, MO ranks #8 of 24 metro areas for cost-of-living-adjusted pay in this job.
Can a nurse practitioner afford rent in St. Louis, MO?
HUD’s fair market rent for a one-bedroom in St. Louis, MO is $989 a month ($1,211 for two bedrooms) — 12% of a median nurse practitioner’s monthly take-home pay. Financial planners usually suggest keeping rent under about 30%.
Related jobs in St. Louis, MO
- Physicians, All Other — $239,200+
- Pharmacist — $138,530
- Physical Therapist — $100,600
- Registered Nurse — $83,180
- Licensed Practical and Licensed Vocational Nurse — $65,120
- Clinical Laboratory Technologist and Technician — $61,830
- Health Technologists and Technicians, All Other — $47,570
- Pharmacy Technician — $45,220