Nurse Practitioner Salary in Indianapolis, IN
Nurse Practitioners in the Indianapolis-Carmel-Greenwood, IN metro area earn a median $130,460 a year — 1% less than the national median. After 2026 taxes, that is $96,616 take-home, or $8,051 a month.
Take-home pay calculator
Pre-filled with the median nurse practitioner salary in Indianapolis, IN. Enter your own offer to see your paycheck.
- Federal income tax$20,044
- Social Security (6.2%)$8,089
- Medicare (1.45%)$1,892
- Indiana income tax$3,819
- Take-home pay$96,616
Marginal rate: 24% federal + 2.95% state
Living in Indianapolis (Marion County)? City residents also pay Indianapolis (Marion County)’s County income tax — about $2,615 a year on this salary — which lowers take-home pay to $94,001 ($7,833 a month). Choose “Indianapolis (Marion County)” under City income tax in the calculator. Suburban residents usually don’t pay it.
Got an offer somewhere else? Compare it with this one after taxes and rent →
Nurse Practitioner pay by experience in Indianapolis, IN
| Percentile | Salary | Hourly | Take-home / yr | Per month |
|---|---|---|---|---|
| 10th percentile (entry level) | $106,500 | $51.20 | $80,641 | $6,720 |
| 25th percentile | $122,720 | $59.00 | $91,554 | $7,630 |
| Median (50th) | $130,460 | $62.72 | $96,616 | $8,051 |
| 75th percentile | $136,130 | $65.45 | $100,325 | $8,360 |
| 90th percentile (top earners) | $152,090 | $73.12 | $110,762 | $9,230 |
Wages: BLS Occupational Employment and Wage Statistics, May 2025. Take-home: single filer, Indiana resident, 2026 tax rules.
What $130,460 buys in Indianapolis, IN
Prices in Indianapolis, IN are 4.3% lower than the U.S. average (housing costs are 11% below the national average). Adjusted for local prices, a median nurse practitioner's $96,616 take-home pay has the buying power of $100,962 in a typical American city.
Rents: HUD Fair Market Rents, FY2026 (40th-percentile gross rent incl. utilities). Price levels: BEA Regional Price Parities, 2024.
Nurse Practitioner jobs are about as common in Indianapolis, IN as in the U.S. overall (location quotient 1.10).
Best-paying cities for nurse practitioners, adjusted for cost of living
Indianapolis, IN ranks #7 of 24 metro areas once taxes and local prices are taken into account.
| # | Metro area | Median salary | Take-home | Real value* |
|---|---|---|---|---|
| 1 | San Francisco, CA | $219,080 | $143,890 | $124,458 |
| 2 | Houston, TX | $134,560 | $103,238 | $104,673 |
| 3 | Cleveland, OH | $130,800 | $97,853 | $104,184 |
| 4 | Kansas City, MO | $130,760 | $95,432 | $103,122 |
| 5 | New York, NY | $163,340 | $114,312 | $101,554 |
| 6 | Cincinnati, OH | $128,700 | $96,476 | $101,159 |
| 7 | Indianapolis, IN | $130,460 | $96,616 | $100,962 |
| 8 | St. Louis, MO | $131,580 | $95,954 | $100,911 |
*Take-home pay divided by the BEA price level, so every city is measured in U.S.-average dollars. See all 24 metros →
About the job: nurse practitioners
Diagnose and treat acute, episodic, or chronic illness, independently or as part of a healthcare team. May focus on health promotion and disease prevention. May order, perform, or interpret diagnostic tests such as lab work and x rays. May prescribe medication. Must be registered nurses who have specialized graduate education.
- Typical education
- Master's degree
- Work experience
- None required
- On-the-job training
- None
- Job outlook, 2025–35
- +41.0% (much faster than average)
Source: BLS Standard Occupational Classification and Employment Projections, 2025–35.
Frequently asked questions
How much does a nurse practitioner make in Indianapolis, IN?
The median nurse practitioner salary in the Indianapolis-Carmel-Greenwood, IN metro area is $130,460 a year, or about $62.72 an hour, according to the Bureau of Labor Statistics (May 2025). The middle half earn between $122,720 and $136,130.
What is a nurse practitioner’s take-home pay in Indianapolis, IN?
On the median $130,460 salary, a single filer living in Indiana takes home about $96,616 a year ($8,051 a month) after federal tax, Social Security, Medicare and $3,819 in Indiana taxes in 2026.
Is Indianapolis, IN a good place to work as a nurse practitioner?
Pay here is 1% below the national median of $132,300. Local prices are 4.3% below the U.S. average, so the take-home pay buys what $100,962 would in a typical U.S. city. Indianapolis, IN ranks #7 of 24 metro areas for cost-of-living-adjusted pay in this job.
Can a nurse practitioner afford rent in Indianapolis, IN?
HUD’s fair market rent for a one-bedroom in Indianapolis, IN is $1,242 a month ($1,454 for two bedrooms) — 15% of a median nurse practitioner’s monthly take-home pay. Financial planners usually suggest keeping rent under about 30%.
Related jobs in Indianapolis, IN
- Physicians, All Other — $239,200+
- Physical Therapist — $103,770
- Registered Nurse — $84,230
- Licensed Practical and Licensed Vocational Nurse — $67,200
- Clinical Laboratory Technologist and Technician — $58,910
- Pharmacy Technician — $45,540
- Psychiatric Technician — $44,710