Natural Sciences Manager Salary in San Francisco, CA
Natural Sciences Managers in the San Francisco-Oakland-Fremont, CA metro area earn a median $225,230 a year — 35% more than the national median. After 2026 taxes, that is $147,276 take-home, or $12,273 a month.
Take-home pay calculator
Pre-filled with the median natural sciences manager salary in San Francisco, CA. Enter your own offer to see your paycheck.
- Federal income tax$43,378
- Social Security (6.2%)$11,439
- Medicare (1.45%)$3,493
- California income tax$16,717
- CA State Disability Insurance (SDI)$2,928
- Take-home pay$147,276
Marginal rate: 32% federal + 9.30% state
Natural Sciences Manager pay by experience in San Francisco, CA
| Percentile | Salary | Hourly | Take-home / yr | Per month |
|---|---|---|---|---|
| 10th percentile (entry level) | $158,270 | $76.09 | $106,897 | $8,908 |
| 25th percentile | $184,110 | $88.51 | $121,819 | $10,152 |
| Median (50th) | $225,230 | $108.28 | $147,276 | $12,273 |
| 75th percentile | $322,670+ | $155.13 | $199,406 | $16,617 |
| 90th percentile (top earners) | $338,660+ | $162.82 | $207,729 | $17,311 |
Wages: BLS Occupational Employment and Wage Statistics, May 2025. Take-home: single filer, California resident, 2026 tax rules.
What $225,230 buys in San Francisco, CA
Prices in San Francisco, CA are 15.6% higher than the U.S. average (housing costs are 1.95× the national average). Adjusted for local prices, a median natural sciences manager's $147,276 take-home pay has the buying power of $127,387 in a typical American city.
Rents: HUD Fair Market Rents, FY2026 (40th-percentile gross rent incl. utilities). Price levels: BEA Regional Price Parities, 2024.
San Francisco, CA has 3.3× the national concentration of natural sciences manager jobs — a strong local market for this occupation.
Best-paying cities for natural sciences managers, adjusted for cost of living
San Francisco, CA ranks #6 of 33 metro areas once taxes and local prices are taken into account.
| # | Metro area | Median salary | Take-home | Real value* |
|---|---|---|---|---|
| 1 | Boston, MA | $239,200+ | $195,208 | $180,304 |
| 2 | San Jose, CA | $239,200+ | $168,514 | $152,608 |
| 3 | Worcester, MA | $212,600 | $147,797 | $144,160 |
| 4 | Seattle, WA | $203,150 | $151,247 | $136,095 |
| 5 | Durham, NC | $183,540 | $129,901 | $133,134 |
| 6 | San Francisco, CA | $225,230 | $147,276 | $127,387 |
| 7 | Charlotte, NC | $173,160 | $123,221 | $126,577 |
| 8 | Raleigh, NC | $173,510 | $123,446 | $125,764 |
*Take-home pay divided by the BEA price level, so every city is measured in U.S.-average dollars. See all 33 metros →
Natural Sciences Manager salaries elsewhere in California
- San Jose, CA — $239,200+
- San Diego, CA — $207,200
- Los Angeles, CA — $193,340
- Sacramento, CA — $170,010
Frequently asked questions
How much does a natural sciences manager make in San Francisco, CA?
The median natural sciences manager salary in the San Francisco-Oakland-Fremont, CA metro area is $225,230 a year, or about $108.28 an hour, according to the Bureau of Labor Statistics (May 2025). The middle half earn between $184,110 and $239,200+.
What is a natural sciences manager’s take-home pay in San Francisco, CA?
On the median $225,230 salary, a single filer living in California takes home about $147,276 a year ($12,273 a month) after federal tax, Social Security, Medicare and $19,645 in California taxes in 2026.
Is San Francisco, CA a good place to work as a natural sciences manager?
Pay here is 35% above the national median of $167,220. Local prices are 15.6% above the U.S. average, so the take-home pay buys what $127,387 would in a typical U.S. city. San Francisco, CA ranks #6 of 33 metro areas for cost-of-living-adjusted pay in this job.
Can a natural sciences manager afford rent in San Francisco, CA?
HUD’s fair market rent for a one-bedroom in San Francisco, CA is $2,620 a month ($3,187 for two bedrooms) — 21% of a median natural sciences manager’s monthly take-home pay. Financial planners usually suggest keeping rent under about 30%.
Related jobs in San Francisco, CA
- Chief Executive — $239,200+
- Computer and Information Systems Manager — $232,890
- Architectural and Engineering Manager — $221,580
- Marketing Manager — $220,480
- Financial Manager — $216,150
- Managers, All Other — $210,080
- Human Resources Manager — $209,340
- Public Relations Manager — $192,720
- Compensation and Benefits Manager — $188,850
- Advertising and Promotions Manager — $181,250
- Training and Development Manager — $173,530
- Sales Manager — $170,810