Natural Sciences Manager Salary in St. Louis, MO
Natural Sciences Managers in the St. Louis, MO-IL metro area earn a median $158,820 a year — 5% less than the national median. After 2026 taxes, that is $113,292 take-home, or $9,441 a month.
Take-home pay calculator
Pre-filled with the median natural sciences manager salary in St. Louis, MO. Enter your own offer to see your paycheck.
- Federal income tax$26,851
- Social Security (6.2%)$9,847
- Medicare (1.45%)$2,303
- Missouri income tax$6,527
- Take-home pay$113,292
Marginal rate: 24% federal + 4.70% state
The St. Louis, MO-IL metro spans Missouri, Illinois. Pick the state you live in — state income tax follows your residence.
Natural Sciences Manager pay by experience in St. Louis, MO
| Percentile | Salary | Hourly | Take-home / yr | Per month |
|---|---|---|---|---|
| 10th percentile (entry level) | $81,460 | $39.16 | $63,246 | $5,270 |
| 25th percentile | $108,060 | $51.95 | $80,709 | $6,726 |
| Median (50th) | $158,820 | $76.36 | $113,292 | $9,441 |
| 75th percentile | $208,620 | $100.30 | $146,408 | $12,201 |
| 90th percentile (top earners) | $275,340+ | $132.38 | $187,724 | $15,644 |
Wages: BLS Occupational Employment and Wage Statistics, May 2025. Take-home: single filer, Missouri resident, 2026 tax rules.
What $158,820 buys in St. Louis, MO
Prices in St. Louis, MO are 4.9% lower than the U.S. average (housing costs are 21% below the national average). Adjusted for local prices, a median natural sciences manager's $113,292 take-home pay has the buying power of $119,145 in a typical American city.
Rents: HUD Fair Market Rents, FY2026 (40th-percentile gross rent incl. utilities). Price levels: BEA Regional Price Parities, 2024.
Natural Sciences Manager jobs are less concentrated in St. Louis, MO than nationally (location quotient 0.69), so openings may be scarcer.
Best-paying cities for natural sciences managers, adjusted for cost of living
St. Louis, MO ranks #13 of 33 metro areas once taxes and local prices are taken into account.
| # | Metro area | Median salary | Take-home | Real value* |
|---|---|---|---|---|
| 1 | Boston, MA | $239,200+ | $195,208 | $180,304 |
| 2 | San Jose, CA | $239,200+ | $168,514 | $152,608 |
| 3 | Worcester, MA | $212,600 | $147,797 | $144,160 |
| 4 | Seattle, WA | $203,150 | $151,247 | $136,095 |
| 5 | Durham, NC | $183,540 | $129,901 | $133,134 |
| 6 | San Francisco, CA | $225,230 | $147,276 | $127,387 |
| 7 | Charlotte, NC | $173,160 | $123,221 | $126,577 |
| 8 | Raleigh, NC | $173,510 | $123,446 | $125,764 |
| 13 | St. Louis, MO | $158,820 | $113,292 | $119,145 |
*Take-home pay divided by the BEA price level, so every city is measured in U.S.-average dollars. See all 33 metros →
Frequently asked questions
How much does a natural sciences manager make in St. Louis, MO?
The median natural sciences manager salary in the St. Louis, MO-IL metro area is $158,820 a year, or about $76.36 an hour, according to the Bureau of Labor Statistics (May 2025). The middle half earn between $108,060 and $208,620.
What is a natural sciences manager’s take-home pay in St. Louis, MO?
On the median $158,820 salary, a single filer living in Missouri takes home about $113,292 a year ($9,441 a month) after federal tax, Social Security, Medicare and $6,527 in Missouri taxes in 2026.
Is St. Louis, MO a good place to work as a natural sciences manager?
Pay here is 5% below the national median of $167,220. Local prices are 4.9% below the U.S. average, so the take-home pay buys what $119,145 would in a typical U.S. city. St. Louis, MO ranks #13 of 33 metro areas for cost-of-living-adjusted pay in this job.
Can a natural sciences manager afford rent in St. Louis, MO?
HUD’s fair market rent for a one-bedroom in St. Louis, MO is $989 a month ($1,211 for two bedrooms) — 10% of a median natural sciences manager’s monthly take-home pay. Financial planners usually suggest keeping rent under about 30%.
Related jobs in St. Louis, MO
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- Architectural and Engineering Manager — $162,660
- Financial Manager — $158,780
- Marketing Manager — $137,900
- Purchasing Manager — $135,400
- Human Resources Manager — $133,880
- Managers, All Other — $130,590
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