Nurse Practitioner Salary in Charleston, SC
Nurse Practitioners in the Charleston-North Charleston, SC metro area earn a median $127,780 a year — 3% less than the national median. After 2026 taxes, that is $92,094 take-home, or $7,674 a month.
Take-home pay calculator
Pre-filled with the median nurse practitioner salary in Charleston, SC. Enter your own offer to see your paycheck.
- Federal income tax$19,401
- Social Security (6.2%)$7,922
- Medicare (1.45%)$1,853
- South Carolina income tax$6,510
- Take-home pay$92,094
Marginal rate: 24% federal + 6.00% state
Nurse Practitioner pay by experience in Charleston, SC
| Percentile | Salary | Hourly | Take-home / yr | Per month |
|---|---|---|---|---|
| 10th percentile (entry level) | $103,200 | $49.62 | $76,396 | $6,366 |
| 25th percentile | $117,480 | $56.48 | $85,585 | $7,132 |
| Median (50th) | $127,780 | $61.43 | $92,094 | $7,674 |
| 75th percentile | $133,050 | $63.97 | $95,380 | $7,948 |
| 90th percentile (top earners) | $157,170 | $75.56 | $110,419 | $9,202 |
Wages: BLS Occupational Employment and Wage Statistics, May 2025. Take-home: single filer, South Carolina resident, 2026 tax rules.
What $127,780 buys in Charleston, SC
Prices in Charleston, SC are 1.0% higher than the U.S. average (housing costs are 1.20× the national average). Adjusted for local prices, a median nurse practitioner's $92,094 take-home pay has the buying power of $91,216 in a typical American city.
Rents: HUD Fair Market Rents, FY2026 (40th-percentile gross rent incl. utilities). Price levels: BEA Regional Price Parities, 2024.
Charleston, SC has 1.3× the national concentration of nurse practitioner jobs — a strong local market for this occupation.
Best-paying cities for nurse practitioners, adjusted for cost of living
Charleston, SC ranks #110 of 117 metro areas once taxes and local prices are taken into account.
| # | Metro area | Median salary | Take-home | Real value* |
|---|---|---|---|---|
| 1 | San Jose, CA | $231,560 | $150,760 | $136,530 |
| 2 | San Francisco, CA | $219,080 | $143,890 | $124,458 |
| 3 | Killeen, TX | $138,670 | $106,047 | $116,366 |
| 4 | Tulsa, OK | $139,460 | $100,857 | $113,050 |
| 5 | Sioux Falls, SD | $130,390 | $100,388 | $110,765 |
| 6 | McAllen, TX | $122,550 | $95,029 | $110,634 |
| 7 | Las Vegas, NV | $144,060 | $109,731 | $109,496 |
| 8 | Fresno, CA | $166,570 | $111,690 | $109,330 |
| 110 | Charleston, SC | $127,780 | $92,094 | $91,216 |
*Take-home pay divided by the BEA price level, so every city is measured in U.S.-average dollars. See all 117 metros →
Nurse Practitioner salaries elsewhere in South Carolina
- Greenville, SC — $119,280
- Columbia, SC — $118,470
Frequently asked questions
How much does a nurse practitioner make in Charleston, SC?
The median nurse practitioner salary in the Charleston-North Charleston, SC metro area is $127,780 a year, or about $61.43 an hour, according to the Bureau of Labor Statistics (May 2025). The middle half earn between $117,480 and $133,050.
What is a nurse practitioner’s take-home pay in Charleston, SC?
On the median $127,780 salary, a single filer living in South Carolina takes home about $92,094 a year ($7,674 a month) after federal tax, Social Security, Medicare and $6,510 in South Carolina taxes in 2026.
Is Charleston, SC a good place to work as a nurse practitioner?
Pay here is 3% below the national median of $132,300. Local prices are 1.0% above the U.S. average, so the take-home pay buys what $91,216 would in a typical U.S. city. Charleston, SC ranks #110 of 117 metro areas for cost-of-living-adjusted pay in this job.
Can a nurse practitioner afford rent in Charleston, SC?
HUD’s fair market rent for a one-bedroom in Charleston, SC is $1,630 a month ($1,787 for two bedrooms) — 21% of a median nurse practitioner’s monthly take-home pay. Financial planners usually suggest keeping rent under about 30%.
Related jobs in Charleston, SC
- Physicians, All Other — $163,900
- Pharmacist — $145,950
- Physician Assistant — $128,920
- Physical Therapist — $101,550
- Dental Hygienist — $94,570
- Registered Nurse — $92,800
- Radiologic Technologist and Technician — $72,730
- Licensed Practical and Licensed Vocational Nurse — $64,100
- Medical Records Specialist — $61,950
- Clinical Laboratory Technologist and Technician — $58,050
- Pharmacy Technician — $45,690
- Health Technologists and Technicians, All Other — $44,840