Nurse Practitioner Salary in Greenville, SC
Nurse Practitioners in the Greenville-Anderson-Greer, SC metro area earn a median $119,280 a year — 10% less than the national median. After 2026 taxes, that is $86,744 take-home, or $7,229 a month.
Take-home pay calculator
Pre-filled with the median nurse practitioner salary in Greenville, SC. Enter your own offer to see your paycheck.
- Federal income tax$17,412
- Social Security (6.2%)$7,395
- Medicare (1.45%)$1,730
- South Carolina income tax$6,000
- Take-home pay$86,744
Marginal rate: 22% federal + 6.00% state
Nurse Practitioner pay by experience in Greenville, SC
| Percentile | Salary | Hourly | Take-home / yr | Per month |
|---|---|---|---|---|
| 10th percentile (entry level) | $81,910 | $39.38 | $62,696 | $5,225 |
| 25th percentile | $110,030 | $52.90 | $80,791 | $6,733 |
| Median (50th) | $119,280 | $57.35 | $86,744 | $7,229 |
| 75th percentile | $129,900 | $62.45 | $93,416 | $7,785 |
| 90th percentile (top earners) | $145,570 | $69.99 | $103,186 | $8,599 |
Wages: BLS Occupational Employment and Wage Statistics, May 2025. Take-home: single filer, South Carolina resident, 2026 tax rules.
What $119,280 buys in Greenville, SC
Prices in Greenville, SC are 6.7% lower than the U.S. average (housing costs are 23% below the national average). Adjusted for local prices, a median nurse practitioner's $86,744 take-home pay has the buying power of $93,013 in a typical American city.
Rents: HUD Fair Market Rents, FY2026 (40th-percentile gross rent incl. utilities). Price levels: BEA Regional Price Parities, 2024.
Greenville, SC has 1.2× the national concentration of nurse practitioner jobs — a strong local market for this occupation.
Best-paying cities for nurse practitioners, adjusted for cost of living
Greenville, SC ranks #103 of 117 metro areas once taxes and local prices are taken into account.
| # | Metro area | Median salary | Take-home | Real value* |
|---|---|---|---|---|
| 1 | San Jose, CA | $231,560 | $150,760 | $136,530 |
| 2 | San Francisco, CA | $219,080 | $143,890 | $124,458 |
| 3 | Killeen, TX | $138,670 | $106,047 | $116,366 |
| 4 | Tulsa, OK | $139,460 | $100,857 | $113,050 |
| 5 | Sioux Falls, SD | $130,390 | $100,388 | $110,765 |
| 6 | McAllen, TX | $122,550 | $95,029 | $110,634 |
| 7 | Las Vegas, NV | $144,060 | $109,731 | $109,496 |
| 8 | Fresno, CA | $166,570 | $111,690 | $109,330 |
| 103 | Greenville, SC | $119,280 | $86,744 | $93,013 |
*Take-home pay divided by the BEA price level, so every city is measured in U.S.-average dollars. See all 117 metros →
Nurse Practitioner salaries elsewhere in South Carolina
- Columbia, SC — $118,470
- Charleston, SC — $127,780
Frequently asked questions
How much does a nurse practitioner make in Greenville, SC?
The median nurse practitioner salary in the Greenville-Anderson-Greer, SC metro area is $119,280 a year, or about $57.35 an hour, according to the Bureau of Labor Statistics (May 2025). The middle half earn between $110,030 and $129,900.
What is a nurse practitioner’s take-home pay in Greenville, SC?
On the median $119,280 salary, a single filer living in South Carolina takes home about $86,744 a year ($7,229 a month) after federal tax, Social Security, Medicare and $6,000 in South Carolina taxes in 2026.
Is Greenville, SC a good place to work as a nurse practitioner?
Pay here is 10% below the national median of $132,300. Local prices are 6.7% below the U.S. average, so the take-home pay buys what $93,013 would in a typical U.S. city. Greenville, SC ranks #103 of 117 metro areas for cost-of-living-adjusted pay in this job.
Can a nurse practitioner afford rent in Greenville, SC?
HUD’s fair market rent for a one-bedroom in Greenville, SC is $1,155 a month ($1,288 for two bedrooms) — 16% of a median nurse practitioner’s monthly take-home pay. Financial planners usually suggest keeping rent under about 30%.
Related jobs in Greenville, SC
- Dentists, General — $139,940
- Pharmacist — $135,580
- Physician Assistant — $123,310
- Physical Therapist — $101,020
- Dental Hygienist — $85,290
- Registered Nurse — $81,400
- Radiologic Technologist and Technician — $68,700
- Surgical Technologist — $63,050
- Licensed Practical and Licensed Vocational Nurse — $61,960
- Clinical Laboratory Technologist and Technician — $53,070
- Medical Records Specialist — $53,040
- Veterinary Technologist and Technician — $45,740