Nurse Practitioner Salary in Sioux Falls, SD
Nurse Practitioners in the Sioux Falls, SD-MN metro area earn a median $130,390 a year — 1% less than the national median. After 2026 taxes, that is $100,388 take-home, or $8,366 a month.
Take-home pay calculator
Pre-filled with the median nurse practitioner salary in Sioux Falls, SD. Enter your own offer to see your paycheck.
- Federal income tax$20,028
- Social Security (6.2%)$8,084
- Medicare (1.45%)$1,891
- South Dakota income tax$0
- Take-home pay$100,388
Marginal rate: 24% federal + 0.00% state
The Sioux Falls, SD-MN metro spans South Dakota, Minnesota. Pick the state you live in — state income tax follows your residence.
Nurse Practitioner pay by experience in Sioux Falls, SD
| Percentile | Salary | Hourly | Take-home / yr | Per month |
|---|---|---|---|---|
| 10th percentile (entry level) | $104,220 | $50.11 | $82,149 | $6,846 |
| 25th percentile | $109,680 | $52.73 | $85,990 | $7,166 |
| Median (50th) | $130,390 | $62.69 | $100,388 | $8,366 |
| 75th percentile | $137,600 | $66.15 | $105,316 | $8,776 |
| 90th percentile (top earners) | $159,330 | $76.60 | $120,168 | $10,014 |
Wages: BLS Occupational Employment and Wage Statistics, May 2025. Take-home: single filer, South Dakota resident, 2026 tax rules.
What $130,390 buys in Sioux Falls, SD
Prices in Sioux Falls, SD are 9.4% lower than the U.S. average (housing costs are 22% below the national average). Adjusted for local prices, a median nurse practitioner's $100,388 take-home pay has the buying power of $110,765 in a typical American city.
Rents: HUD Fair Market Rents, FY2026 (40th-percentile gross rent incl. utilities). Price levels: BEA Regional Price Parities, 2024.
Sioux Falls, SD has 1.4× the national concentration of nurse practitioner jobs — a strong local market for this occupation.
Best-paying cities for nurse practitioners, adjusted for cost of living
Sioux Falls, SD ranks #5 of 117 metro areas once taxes and local prices are taken into account.
| # | Metro area | Median salary | Take-home | Real value* |
|---|---|---|---|---|
| 1 | San Jose, CA | $231,560 | $150,760 | $136,530 |
| 2 | San Francisco, CA | $219,080 | $143,890 | $124,458 |
| 3 | Killeen, TX | $138,670 | $106,047 | $116,366 |
| 4 | Tulsa, OK | $139,460 | $100,857 | $113,050 |
| 5 | Sioux Falls, SD | $130,390 | $100,388 | $110,765 |
| 6 | McAllen, TX | $122,550 | $95,029 | $110,634 |
| 7 | Las Vegas, NV | $144,060 | $109,731 | $109,496 |
| 8 | Fresno, CA | $166,570 | $111,690 | $109,330 |
*Take-home pay divided by the BEA price level, so every city is measured in U.S.-average dollars. See all 117 metros →
Frequently asked questions
How much does a nurse practitioner make in Sioux Falls, SD?
The median nurse practitioner salary in the Sioux Falls, SD-MN metro area is $130,390 a year, or about $62.69 an hour, according to the Bureau of Labor Statistics (May 2025). The middle half earn between $109,680 and $137,600.
What is a nurse practitioner’s take-home pay in Sioux Falls, SD?
On the median $130,390 salary, a single filer living in South Dakota takes home about $100,388 a year ($8,366 a month) after federal tax, Social Security, Medicare in 2026.
Is Sioux Falls, SD a good place to work as a nurse practitioner?
Pay here is 1% below the national median of $132,300. Local prices are 9.4% below the U.S. average, so the take-home pay buys what $110,765 would in a typical U.S. city. Sioux Falls, SD ranks #5 of 117 metro areas for cost-of-living-adjusted pay in this job.
Can a nurse practitioner afford rent in Sioux Falls, SD?
HUD’s fair market rent for a one-bedroom in Sioux Falls, SD is $978 a month ($1,150 for two bedrooms) — 12% of a median nurse practitioner’s monthly take-home pay. Financial planners usually suggest keeping rent under about 30%.
Related jobs in Sioux Falls, SD
- Pharmacist — $148,330
- Physical Therapist — $91,470
- Registered Nurse — $75,350
- Radiologic Technologist and Technician — $65,030
- Clinical Laboratory Technologist and Technician — $57,910
- Licensed Practical and Licensed Vocational Nurse — $53,520
- Pharmacy Technician — $45,610