Registered Nurse Salary in Sioux Falls, SD
Registered Nurses in the Sioux Falls, SD-MN metro area earn a median $75,350 a year — 23% less than the national median. After 2026 taxes, that is $61,839 take-home, or $5,153 a month.
Take-home pay calculator
Pre-filled with the median registered nurse salary in Sioux Falls, SD. Enter your own offer to see your paycheck.
- Federal income tax$7,747
- Social Security (6.2%)$4,672
- Medicare (1.45%)$1,093
- South Dakota income tax$0
- Take-home pay$61,839
Marginal rate: 22% federal + 0.00% state
The Sioux Falls, SD-MN metro spans South Dakota, Minnesota. Pick the state you live in — state income tax follows your residence.
Registered Nurse pay by experience in Sioux Falls, SD
| Percentile | Salary | Hourly | Take-home / yr | Per month |
|---|---|---|---|---|
| 10th percentile (entry level) | $54,040 | $25.98 | $45,601 | $3,800 |
| 25th percentile | $65,070 | $31.28 | $54,464 | $4,539 |
| Median (50th) | $75,350 | $36.23 | $61,839 | $5,153 |
| 75th percentile | $81,690 | $39.27 | $66,299 | $5,525 |
| 90th percentile (top earners) | $97,330 | $46.79 | $77,302 | $6,442 |
Wages: BLS Occupational Employment and Wage Statistics, May 2025. Take-home: single filer, South Dakota resident, 2026 tax rules.
What $75,350 buys in Sioux Falls, SD
Prices in Sioux Falls, SD are 9.4% lower than the U.S. average (housing costs are 22% below the national average). Adjusted for local prices, a median registered nurse's $61,839 take-home pay has the buying power of $68,231 in a typical American city.
Rents: HUD Fair Market Rents, FY2026 (40th-percentile gross rent incl. utilities). Price levels: BEA Regional Price Parities, 2024.
Sioux Falls, SD has 2.0× the national concentration of registered nurse jobs — a strong local market for this occupation.
Best-paying cities for registered nurses, adjusted for cost of living
Sioux Falls, SD ranks #301 of 370 metro areas once taxes and local prices are taken into account.
| # | Metro area | Median salary | Take-home | Real value* |
|---|---|---|---|---|
| 1 | San Jose, CA | $216,740 | $142,511 | $129,059 |
| 2 | Vallejo, CA | $203,290 | $134,031 | $123,555 |
| 3 | Santa Rosa, CA | $174,550 | $116,298 | $107,899 |
| 4 | Sacramento, CA | $171,460 | $114,514 | $107,353 |
| 5 | San Francisco, CA | $186,610 | $123,394 | $106,730 |
| 6 | Santa Cruz, CA | $170,960 | $114,225 | $103,939 |
| 7 | Yuba City, CA | $149,320 | $101,728 | $97,597 |
| 8 | Olympia, WA | $125,020 | $96,717 | $93,293 |
| 301 | Sioux Falls, SD | $75,350 | $61,839 | $68,231 |
*Take-home pay divided by the BEA price level, so every city is measured in U.S.-average dollars. See all 370 metros →
Registered Nurse salaries elsewhere in South Dakota
- Rapid City, SD — $79,380
Frequently asked questions
How much does a registered nurse make in Sioux Falls, SD?
The median registered nurse salary in the Sioux Falls, SD-MN metro area is $75,350 a year, or about $36.23 an hour, according to the Bureau of Labor Statistics (May 2025). The middle half earn between $65,070 and $81,690.
What is a registered nurse’s take-home pay in Sioux Falls, SD?
On the median $75,350 salary, a single filer living in South Dakota takes home about $61,839 a year ($5,153 a month) after federal tax, Social Security, Medicare in 2026.
Is Sioux Falls, SD a good place to work as a registered nurse?
Pay here is 23% below the national median of $97,550. Local prices are 9.4% below the U.S. average, so the take-home pay buys what $68,231 would in a typical U.S. city. Sioux Falls, SD ranks #301 of 370 metro areas for cost-of-living-adjusted pay in this job.
Can a registered nurse afford rent in Sioux Falls, SD?
HUD’s fair market rent for a one-bedroom in Sioux Falls, SD is $978 a month ($1,150 for two bedrooms) — 19% of a median registered nurse’s monthly take-home pay. Financial planners usually suggest keeping rent under about 30%.
Related jobs in Sioux Falls, SD
- Pharmacist — $148,330
- Nurse Practitioner — $130,390
- Physical Therapist — $91,470
- Radiologic Technologist and Technician — $65,030
- Clinical Laboratory Technologist and Technician — $57,910
- Licensed Practical and Licensed Vocational Nurse — $53,520
- Pharmacy Technician — $45,610