Pharmacist Salary in Sioux Falls, SD
Pharmacists in the Sioux Falls, SD-MN metro area earn a median $148,330 a year — 5% more than the national median. After 2026 taxes, that is $112,650 take-home, or $9,387 a month.
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- Federal income tax$24,333
- Social Security (6.2%)$9,196
- Medicare (1.45%)$2,151
- South Dakota income tax$0
- Take-home pay$112,650
Marginal rate: 24% federal + 0.00% state
The Sioux Falls, SD-MN metro spans South Dakota, Minnesota. Pick the state you live in — state income tax follows your residence.
Pharmacist pay by experience in Sioux Falls, SD
| Percentile | Salary | Hourly | Take-home / yr | Per month |
|---|---|---|---|---|
| 10th percentile (entry level) | $123,700 | $59.47 | $95,815 | $7,985 |
| 25th percentile | $135,680 | $65.23 | $104,003 | $8,667 |
| Median (50th) | $148,330 | $71.31 | $112,650 | $9,387 |
| 75th percentile | $162,770 | $78.25 | $122,519 | $10,210 |
| 90th percentile (top earners) | $174,070 | $83.69 | $130,243 | $10,854 |
Wages: BLS Occupational Employment and Wage Statistics, May 2025. Take-home: single filer, South Dakota resident, 2026 tax rules.
What $148,330 buys in Sioux Falls, SD
Prices in Sioux Falls, SD are 9.4% lower than the U.S. average (housing costs are 22% below the national average). Adjusted for local prices, a median pharmacist's $112,650 take-home pay has the buying power of $124,295 in a typical American city.
Rents: HUD Fair Market Rents, FY2026 (40th-percentile gross rent incl. utilities). Price levels: BEA Regional Price Parities, 2024.
Sioux Falls, SD has 1.9× the national concentration of pharmacist jobs — a strong local market for this occupation.
Best-paying cities for pharmacists, adjusted for cost of living
Sioux Falls, SD ranks #2 of 120 metro areas once taxes and local prices are taken into account.
| # | Metro area | Median salary | Take-home | Real value* |
|---|---|---|---|---|
| 1 | Rochester, MN | $164,250 | $113,470 | $124,938 |
| 2 | Sioux Falls, SD | $148,330 | $112,650 | $124,295 |
| 3 | McAllen, TX | $137,700 | $105,384 | $122,689 |
| 4 | San Antonio, TX | $150,500 | $114,133 | $120,500 |
| 5 | Shreveport, LA | $137,970 | $101,816 | $120,114 |
| 6 | San Jose, CA | $199,040 | $131,343 | $118,945 |
| 7 | Spartanburg, SC | $153,610 | $108,199 | $118,833 |
| 8 | Fargo, ND | $142,040 | $106,840 | $117,573 |
*Take-home pay divided by the BEA price level, so every city is measured in U.S.-average dollars. See all 120 metros →
Frequently asked questions
How much does a pharmacist make in Sioux Falls, SD?
The median pharmacist salary in the Sioux Falls, SD-MN metro area is $148,330 a year, or about $71.31 an hour, according to the Bureau of Labor Statistics (May 2025). The middle half earn between $135,680 and $162,770.
What is a pharmacist’s take-home pay in Sioux Falls, SD?
On the median $148,330 salary, a single filer living in South Dakota takes home about $112,650 a year ($9,387 a month) after federal tax, Social Security, Medicare in 2026.
Is Sioux Falls, SD a good place to work as a pharmacist?
Pay here is 5% above the national median of $140,910. Local prices are 9.4% below the U.S. average, so the take-home pay buys what $124,295 would in a typical U.S. city. Sioux Falls, SD ranks #2 of 120 metro areas for cost-of-living-adjusted pay in this job.
Can a pharmacist afford rent in Sioux Falls, SD?
HUD’s fair market rent for a one-bedroom in Sioux Falls, SD is $978 a month ($1,150 for two bedrooms) — 10% of a median pharmacist’s monthly take-home pay. Financial planners usually suggest keeping rent under about 30%.
Related jobs in Sioux Falls, SD
- Nurse Practitioner — $130,390
- Physical Therapist — $91,470
- Registered Nurse — $75,350
- Radiologic Technologist and Technician — $65,030
- Clinical Laboratory Technologist and Technician — $57,910
- Licensed Practical and Licensed Vocational Nurse — $53,520
- Pharmacy Technician — $45,610