Registered Nurse Salary in Greenville, SC
Registered Nurses in the Greenville-Anderson-Greer, SC metro area earn a median $81,400 a year — 17% less than the national median. After 2026 taxes, that is $62,368 take-home, or $5,197 a month.
Take-home pay calculator
Pre-filled with the median registered nurse salary in Greenville, SC. Enter your own offer to see your paycheck.
- Federal income tax$9,078
- Social Security (6.2%)$5,047
- Medicare (1.45%)$1,180
- South Carolina income tax$3,727
- Take-home pay$62,368
Marginal rate: 22% federal + 6.00% state
Registered Nurse pay by experience in Greenville, SC
| Percentile | Salary | Hourly | Take-home / yr | Per month |
|---|---|---|---|---|
| 10th percentile (entry level) | $68,530 | $32.95 | $54,086 | $4,507 |
| 25th percentile | $78,060 | $37.53 | $60,219 | $5,018 |
| Median (50th) | $81,400 | $39.13 | $62,368 | $5,197 |
| 75th percentile | $96,580 | $46.43 | $72,136 | $6,011 |
| 90th percentile (top earners) | $100,630 | $48.38 | $74,743 | $6,229 |
Wages: BLS Occupational Employment and Wage Statistics, May 2025. Take-home: single filer, South Carolina resident, 2026 tax rules.
What $81,400 buys in Greenville, SC
Prices in Greenville, SC are 6.7% lower than the U.S. average (housing costs are 23% below the national average). Adjusted for local prices, a median registered nurse's $62,368 take-home pay has the buying power of $66,875 in a typical American city.
Rents: HUD Fair Market Rents, FY2026 (40th-percentile gross rent incl. utilities). Price levels: BEA Regional Price Parities, 2024.
Registered Nurse jobs are about as common in Greenville, SC as in the U.S. overall (location quotient 1.03).
Best-paying cities for registered nurses, adjusted for cost of living
Greenville, SC ranks #330 of 370 metro areas once taxes and local prices are taken into account.
| # | Metro area | Median salary | Take-home | Real value* |
|---|---|---|---|---|
| 1 | San Jose, CA | $216,740 | $142,511 | $129,059 |
| 2 | Vallejo, CA | $203,290 | $134,031 | $123,555 |
| 3 | Santa Rosa, CA | $174,550 | $116,298 | $107,899 |
| 4 | Sacramento, CA | $171,460 | $114,514 | $107,353 |
| 5 | San Francisco, CA | $186,610 | $123,394 | $106,730 |
| 6 | Santa Cruz, CA | $170,960 | $114,225 | $103,939 |
| 7 | Yuba City, CA | $149,320 | $101,728 | $97,597 |
| 8 | Olympia, WA | $125,020 | $96,717 | $93,293 |
| 330 | Greenville, SC | $81,400 | $62,368 | $66,875 |
*Take-home pay divided by the BEA price level, so every city is measured in U.S.-average dollars. See all 370 metros →
Registered Nurse salaries elsewhere in South Carolina
- Sumter, SC — $86,260
- Florence, SC — $81,170
- Spartanburg, SC — $82,360
- Charleston, SC — $92,800
- Columbia, SC — $81,920
- Myrtle Beach, SC — $80,640
- Hilton Head Island, SC — $81,400
Frequently asked questions
How much does a registered nurse make in Greenville, SC?
The median registered nurse salary in the Greenville-Anderson-Greer, SC metro area is $81,400 a year, or about $39.13 an hour, according to the Bureau of Labor Statistics (May 2025). The middle half earn between $78,060 and $96,580.
What is a registered nurse’s take-home pay in Greenville, SC?
On the median $81,400 salary, a single filer living in South Carolina takes home about $62,368 a year ($5,197 a month) after federal tax, Social Security, Medicare and $3,727 in South Carolina taxes in 2026.
Is Greenville, SC a good place to work as a registered nurse?
Pay here is 17% below the national median of $97,550. Local prices are 6.7% below the U.S. average, so the take-home pay buys what $66,875 would in a typical U.S. city. Greenville, SC ranks #330 of 370 metro areas for cost-of-living-adjusted pay in this job.
Can a registered nurse afford rent in Greenville, SC?
HUD’s fair market rent for a one-bedroom in Greenville, SC is $1,155 a month ($1,288 for two bedrooms) — 22% of a median registered nurse’s monthly take-home pay. Financial planners usually suggest keeping rent under about 30%.
Related jobs in Greenville, SC
- Dentists, General — $139,940
- Pharmacist — $135,580
- Physician Assistant — $123,310
- Nurse Practitioner — $119,280
- Physical Therapist — $101,020
- Dental Hygienist — $85,290
- Radiologic Technologist and Technician — $68,700
- Surgical Technologist — $63,050
- Licensed Practical and Licensed Vocational Nurse — $61,960
- Clinical Laboratory Technologist and Technician — $53,070
- Medical Records Specialist — $53,040
- Veterinary Technologist and Technician — $45,740