Registered Nurse Salary in Spartanburg, SC
Registered Nurses in the Spartanburg, SC metro area earn a median $82,360 a year — 16% less than the national median. After 2026 taxes, that is $62,986 take-home, or $5,249 a month.
Take-home pay calculator
Pre-filled with the median registered nurse salary in Spartanburg, SC. Enter your own offer to see your paycheck.
- Federal income tax$9,289
- Social Security (6.2%)$5,106
- Medicare (1.45%)$1,194
- South Carolina income tax$3,784
- Take-home pay$62,986
Marginal rate: 22% federal + 6.00% state
Registered Nurse pay by experience in Spartanburg, SC
| Percentile | Salary | Hourly | Take-home / yr | Per month |
|---|---|---|---|---|
| 10th percentile (entry level) | $70,180 | $33.74 | $55,148 | $4,596 |
| 25th percentile | $70,250 | $33.77 | $55,193 | $4,599 |
| Median (50th) | $82,360 | $39.60 | $62,986 | $5,249 |
| 75th percentile | $85,470 | $41.09 | $64,987 | $5,416 |
| 90th percentile (top earners) | $101,420 | $48.76 | $75,251 | $6,271 |
Wages: BLS Occupational Employment and Wage Statistics, May 2025. Take-home: single filer, South Carolina resident, 2026 tax rules.
What $82,360 buys in Spartanburg, SC
Prices in Spartanburg, SC are 8.9% lower than the U.S. average (housing costs are 32% below the national average). Adjusted for local prices, a median registered nurse's $62,986 take-home pay has the buying power of $69,176 in a typical American city.
Rents: HUD Fair Market Rents, FY2026 (40th-percentile gross rent incl. utilities). Price levels: BEA Regional Price Parities, 2024.
Spartanburg, SC has 1.2× the national concentration of registered nurse jobs — a strong local market for this occupation.
Best-paying cities for registered nurses, adjusted for cost of living
Spartanburg, SC ranks #271 of 370 metro areas once taxes and local prices are taken into account.
| # | Metro area | Median salary | Take-home | Real value* |
|---|---|---|---|---|
| 1 | San Jose, CA | $216,740 | $142,511 | $129,059 |
| 2 | Vallejo, CA | $203,290 | $134,031 | $123,555 |
| 3 | Santa Rosa, CA | $174,550 | $116,298 | $107,899 |
| 4 | Sacramento, CA | $171,460 | $114,514 | $107,353 |
| 5 | San Francisco, CA | $186,610 | $123,394 | $106,730 |
| 6 | Santa Cruz, CA | $170,960 | $114,225 | $103,939 |
| 7 | Yuba City, CA | $149,320 | $101,728 | $97,597 |
| 8 | Olympia, WA | $125,020 | $96,717 | $93,293 |
| 271 | Spartanburg, SC | $82,360 | $62,986 | $69,176 |
*Take-home pay divided by the BEA price level, so every city is measured in U.S.-average dollars. See all 370 metros →
Registered Nurse salaries elsewhere in South Carolina
- Sumter, SC — $86,260
- Florence, SC — $81,170
- Charleston, SC — $92,800
- Columbia, SC — $81,920
- Greenville, SC — $81,400
- Myrtle Beach, SC — $80,640
- Hilton Head Island, SC — $81,400
Frequently asked questions
How much does a registered nurse make in Spartanburg, SC?
The median registered nurse salary in the Spartanburg, SC metro area is $82,360 a year, or about $39.60 an hour, according to the Bureau of Labor Statistics (May 2025). The middle half earn between $70,250 and $85,470.
What is a registered nurse’s take-home pay in Spartanburg, SC?
On the median $82,360 salary, a single filer living in South Carolina takes home about $62,986 a year ($5,249 a month) after federal tax, Social Security, Medicare and $3,784 in South Carolina taxes in 2026.
Is Spartanburg, SC a good place to work as a registered nurse?
Pay here is 16% below the national median of $97,550. Local prices are 8.9% below the U.S. average, so the take-home pay buys what $69,176 would in a typical U.S. city. Spartanburg, SC ranks #271 of 370 metro areas for cost-of-living-adjusted pay in this job.
Can a registered nurse afford rent in Spartanburg, SC?
HUD’s fair market rent for a one-bedroom in Spartanburg, SC is $1,061 a month ($1,176 for two bedrooms) — 20% of a median registered nurse’s monthly take-home pay. Financial planners usually suggest keeping rent under about 30%.
Related jobs in Spartanburg, SC
- Pharmacist — $153,610
- Pharmacy Technician — $43,840
- Emergency Medical Technician — $39,980