Nurse Practitioner Salary in St. Louis, MO
Nurse Practitioners in the St. Louis, MO-IL metro area earn a median $131,580 a year — 1% less than the national median. After 2026 taxes, that is $95,954 take-home, or $7,996 a month.
Take-home pay calculator
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- Federal income tax$20,313
- Social Security (6.2%)$8,158
- Medicare (1.45%)$1,908
- Missouri income tax$5,247
- Take-home pay$95,954
Marginal rate: 24% federal + 4.70% state
The St. Louis, MO-IL metro spans Missouri, Illinois. Pick the state you live in — state income tax follows your residence.
Nurse Practitioner pay by experience in St. Louis, MO
| Percentile | Salary | Hourly | Take-home / yr | Per month |
|---|---|---|---|---|
| 10th percentile (entry level) | $108,340 | $52.09 | $80,893 | $6,741 |
| 25th percentile | $127,460 | $61.28 | $93,332 | $7,778 |
| Median (50th) | $131,580 | $63.26 | $95,954 | $7,996 |
| 75th percentile | $154,500 | $74.28 | $110,543 | $9,212 |
| 90th percentile (top earners) | $164,280 | $78.98 | $116,768 | $9,731 |
Wages: BLS Occupational Employment and Wage Statistics, May 2025. Take-home: single filer, Missouri resident, 2026 tax rules.
What $131,580 buys in St. Louis, MO
Prices in St. Louis, MO are 4.9% lower than the U.S. average (housing costs are 21% below the national average). Adjusted for local prices, a median nurse practitioner's $95,954 take-home pay has the buying power of $100,911 in a typical American city.
Rents: HUD Fair Market Rents, FY2026 (40th-percentile gross rent incl. utilities). Price levels: BEA Regional Price Parities, 2024.
St. Louis, MO has 1.2× the national concentration of nurse practitioner jobs — a strong local market for this occupation.
Best-paying cities for nurse practitioners, adjusted for cost of living
St. Louis, MO ranks #47 of 117 metro areas once taxes and local prices are taken into account.
| # | Metro area | Median salary | Take-home | Real value* |
|---|---|---|---|---|
| 1 | San Jose, CA | $231,560 | $150,760 | $136,530 |
| 2 | San Francisco, CA | $219,080 | $143,890 | $124,458 |
| 3 | Killeen, TX | $138,670 | $106,047 | $116,366 |
| 4 | Tulsa, OK | $139,460 | $100,857 | $113,050 |
| 5 | Sioux Falls, SD | $130,390 | $100,388 | $110,765 |
| 6 | McAllen, TX | $122,550 | $95,029 | $110,634 |
| 7 | Las Vegas, NV | $144,060 | $109,731 | $109,496 |
| 8 | Fresno, CA | $166,570 | $111,690 | $109,330 |
| 47 | St. Louis, MO | $131,580 | $95,954 | $100,911 |
*Take-home pay divided by the BEA price level, so every city is measured in U.S.-average dollars. See all 117 metros →
Nurse Practitioner salaries elsewhere in Missouri
- Springfield, MO — $125,630
- Kansas City, MO — $130,760
Frequently asked questions
How much does a nurse practitioner make in St. Louis, MO?
The median nurse practitioner salary in the St. Louis, MO-IL metro area is $131,580 a year, or about $63.26 an hour, according to the Bureau of Labor Statistics (May 2025). The middle half earn between $127,460 and $154,500.
What is a nurse practitioner’s take-home pay in St. Louis, MO?
On the median $131,580 salary, a single filer living in Missouri takes home about $95,954 a year ($7,996 a month) after federal tax, Social Security, Medicare and $5,247 in Missouri taxes in 2026.
Is St. Louis, MO a good place to work as a nurse practitioner?
Pay here is 1% below the national median of $132,300. Local prices are 4.9% below the U.S. average, so the take-home pay buys what $100,911 would in a typical U.S. city. St. Louis, MO ranks #47 of 117 metro areas for cost-of-living-adjusted pay in this job.
Can a nurse practitioner afford rent in St. Louis, MO?
HUD’s fair market rent for a one-bedroom in St. Louis, MO is $989 a month ($1,211 for two bedrooms) — 12% of a median nurse practitioner’s monthly take-home pay. Financial planners usually suggest keeping rent under about 30%.
Related jobs in St. Louis, MO
- Physicians, All Other — $239,200+
- Nurse Anesthetist — $232,300
- Dentists, General — $210,430
- Pharmacist — $138,530
- Physician Assistant — $136,120
- Veterinarian — $122,460
- Physical Therapist — $100,600
- Diagnostic Medical Sonographer — $98,990
- Dental Hygienist — $97,650
- Occupational Therapist — $95,770
- Speech-Language Pathologist — $86,480
- Magnetic Resonance Imaging Technologist — $83,330