Nurse Practitioner Salary in San Antonio, TX
Nurse Practitioners in the San Antonio-New Braunfels, TX metro area earn a median $131,770 a year — 0% less than the national median. After 2026 taxes, that is $101,331 take-home, or $8,444 a month.
Take-home pay calculator
Pre-filled with the median nurse practitioner salary in San Antonio, TX. Enter your own offer to see your paycheck.
- Federal income tax$20,359
- Social Security (6.2%)$8,170
- Medicare (1.45%)$1,911
- Texas income tax$0
- Take-home pay$101,331
Marginal rate: 24% federal + 0.00% state
Nurse Practitioner pay by experience in San Antonio, TX
| Percentile | Salary | Hourly | Take-home / yr | Per month |
|---|---|---|---|---|
| 10th percentile (entry level) | $102,080 | $49.08 | $80,643 | $6,720 |
| 25th percentile | $116,150 | $55.84 | $90,542 | $7,545 |
| Median (50th) | $131,770 | $63.35 | $101,331 | $8,444 |
| 75th percentile | $146,940 | $70.64 | $111,699 | $9,308 |
| 90th percentile (top earners) | $159,580 | $76.72 | $120,339 | $10,028 |
Wages: BLS Occupational Employment and Wage Statistics, May 2025. Take-home: single filer, Texas resident, 2026 tax rules.
What $131,770 buys in San Antonio, TX
Prices in San Antonio, TX are 5.3% lower than the U.S. average (housing costs are 5% below the national average). Adjusted for local prices, a median nurse practitioner's $101,331 take-home pay has the buying power of $106,984 in a typical American city.
Rents: HUD Fair Market Rents, FY2026 (40th-percentile gross rent incl. utilities). Price levels: BEA Regional Price Parities, 2024.
Nurse Practitioner jobs are less concentrated in San Antonio, TX than nationally (location quotient 0.76), so openings may be scarcer.
Best-paying cities for nurse practitioners, adjusted for cost of living
San Antonio, TX ranks #15 of 117 metro areas once taxes and local prices are taken into account.
| # | Metro area | Median salary | Take-home | Real value* |
|---|---|---|---|---|
| 1 | San Jose, CA | $231,560 | $150,760 | $136,530 |
| 2 | San Francisco, CA | $219,080 | $143,890 | $124,458 |
| 3 | Killeen, TX | $138,670 | $106,047 | $116,366 |
| 4 | Tulsa, OK | $139,460 | $100,857 | $113,050 |
| 5 | Sioux Falls, SD | $130,390 | $100,388 | $110,765 |
| 6 | McAllen, TX | $122,550 | $95,029 | $110,634 |
| 7 | Las Vegas, NV | $144,060 | $109,731 | $109,496 |
| 8 | Fresno, CA | $166,570 | $111,690 | $109,330 |
| 15 | San Antonio, TX | $131,770 | $101,331 | $106,984 |
*Take-home pay divided by the BEA price level, so every city is measured in U.S.-average dollars. See all 117 metros →
Nurse Practitioner salaries elsewhere in Texas
- Killeen, TX — $138,670
- McAllen, TX — $122,550
- El Paso, TX — $127,110
- Houston, TX — $134,560
- Austin, TX — $128,050
- Dallas, TX — $130,980
Frequently asked questions
How much does a nurse practitioner make in San Antonio, TX?
The median nurse practitioner salary in the San Antonio-New Braunfels, TX metro area is $131,770 a year, or about $63.35 an hour, according to the Bureau of Labor Statistics (May 2025). The middle half earn between $116,150 and $146,940.
What is a nurse practitioner’s take-home pay in San Antonio, TX?
On the median $131,770 salary, a single filer living in Texas takes home about $101,331 a year ($8,444 a month) after federal tax, Social Security, Medicare in 2026.
Is San Antonio, TX a good place to work as a nurse practitioner?
Pay here is 0% below the national median of $132,300. Local prices are 5.3% below the U.S. average, so the take-home pay buys what $106,984 would in a typical U.S. city. San Antonio, TX ranks #15 of 117 metro areas for cost-of-living-adjusted pay in this job.
Can a nurse practitioner afford rent in San Antonio, TX?
HUD’s fair market rent for a one-bedroom in San Antonio, TX is $1,171 a month ($1,419 for two bedrooms) — 14% of a median nurse practitioner’s monthly take-home pay. Financial planners usually suggest keeping rent under about 30%.
Related jobs in San Antonio, TX
- Physicians, All Other — $239,200+
- Family Medicine Physician — $233,780
- Dentists, General — $162,140
- Pharmacist — $150,500
- Physician Assistant — $140,160
- Veterinarian — $128,550
- Optometrist — $111,780
- Occupational Therapist — $107,650
- Physical Therapist — $106,010
- Dental Hygienist — $98,480
- Registered Nurse — $94,370
- Speech-Language Pathologist — $92,700